Role for Endocannabinoids in Spinal Manipulative Therapy Analgesia?. (15th July 2019)

• Record Type: Journal Article
• Authors: Onifer, Stephen M.; Sozio, Randall S.; Long, Cynthia R.
• Other Names: Vannacci Alfredo Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2019(2019)
• Publication Date: 2019-07-15
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2019/2878352
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Chronic pain is quite prevalent and causes significant disabilities and socioeconomic burdens. Spinal manipulative therapy and other manipulative therapies are used to manage chronic pain. There is a critical knowledge gap about mechanisms and sites of action in spinal manipulative therapy pain relief, especially the short-term analgesia that occurs following a treatment. Endocannabinoids are an activity-dependent neurotransmitter system that acts as a short-term synaptic circuit breaker. This review describes both clinical research and basic research evidence suggesting that endocannabinoids contribute to short-term manipulative therapy analgesia. Determining endocannabinoids involvement in spinal manipulative therapy will improve its clinical efficacy when results from basic science and clinical research are translated.