Gene Expression Profiles of the Cochlea and Vestibular Endorgans: Localization and Function of Genes Causing Deafness. (May 2015)

• Record Type: Journal Article
• Authors: Nishio, Shin-ya; Hattori, Mitsuru; Moteki, Hideaki; Tsukada, Keita; Miyagawa, Maiko; Naito, Takehiko; Yoshimura, Hidekane; Iwasa, Yoh-ichiro; Mori, Kentaro; Shima, Yutaka; Sakuma, Naoko; Usami, Shin-ichi
• Is Part Of: Annals of otology, rhinology & laryngology. Volume 124:Number 1(2015) Supplement 1
• Page Start: 6S
• Page End: 48S
• Publication Date: 2015-05
• Subjects: deafness -- gene expression -- immunocytochemistry -- in situ hybridization -- localization; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1177/0003489415575549
• Languages: English
• ISSNs: 0003-4894

Abstract

Objectives: We sought to elucidate the gene expression profiles of the causative genes as well as the localization of the encoded proteins involved in hereditary hearing loss. Methods: Relevant articles (as of September 2014) were searched in PubMed databases, and the gene symbols of the genes reported to be associated with deafness were located on the Hereditary Hearing Loss Homepage using localization, expression, and distribution as keywords. Results: Our review of the literature allowed us to systematize the gene expression profiles for genetic deafness in the inner ear, clarifying the unique functions and specific expression patterns of these genes in the cochlea and vestibular endorgans. Conclusions: The coordinated actions of various encoded molecules are essential for the normal development and maintenance of auditory and vestibular function.