Novel Starch-PVA Polymer for Microparticle Preparation and Optimization Using Factorial Design Study. (12th January 2015)

• Record Type: Journal Article
• Authors: Chattopadhyay, Helen; De, Amit Kumar; Datta, Sriparna
• Other Names: Mutalik Srinivas Academic Editor.
• Is Part Of: International scholarly research notices. Volume 2015(2015)
• Publication Date: 2015-01-12
• Subjects: Medical sciences -- Periodicals; Life sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; Biomedical Technology; Biological Science Disciplines; Medicine; Life sciences; Medical sciences; Medicine; Science; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; Electronic journals
• DOI: 10.1155/2015/261476
• Languages: English
• ISSNs: 2356-7872

Abstract

Abstract : The aim of our present work was to optimize the ratio of a very novel polymer, starch-polyvinyl alcohol (PVA), for controlled delivery of Ornidazole. Polymer-coated drug microparticles were prepared by emulsion method. Microscopic study, scanning electron microscopic study, and atomic force microscopic study revealed that the microparticles were within 10 micrometers of size with smooth spherical shape. The Fourier transform infrared spectroscopy showed absence of drug polymer interaction. A statistical 3 2 full factorial design was used to study the effect of different concentration of starch and PVA on the drug release profile. The three-dimensional plots gave us an idea about the contribution of each factor on the release kinetics. Hence this novel polymer of starch and polyvinyl alcohol can be utilized for control release of the drug from a targeted delivery device.