Primary Hyperparathyroidism and Pancreatitis: A Rare Association with Multiple Facets. (27th September 2016)

• Record Type: Journal Article
• Authors: Diallo, I.; Fall, C. A.; Ndiaye, B.; Mbaye, M.; Diedhiou, I.; Ndiaye, A. R.; Diawara, P. S.; Fall, F.; Mbaye, P. S.; Gning, S. B.
• Other Names: Pezzilli Raffaele Academic Editor.
• Is Part Of: International scholarly research notices. Volume 2016(2016)
• Publication Date: 2016-09-27
• Subjects: Medical sciences -- Periodicals; Life sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; Biomedical Technology; Biological Science Disciplines; Medicine; Life sciences; Medical sciences; Medicine; Science; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; Electronic journals
• DOI: 10.1155/2016/7294274
• Languages: English
• ISSNs: 2356-7872

Abstract

Abstract : Primary hyperparathyroidism (PHPT) is rarely associated with the occurrence of acute or chronic pancreatitis. Hypercalcemia plays a major role in the pathogenesis. We report five cases of pancreatitis revealing PHPT. Patients and Methods . This is a retrospective study of 4 years, including all patients admitted to intensive care unit or gastroenterology department, for an acute or chronic pancreatitis revealing primary hyperparathyroidism. Results . We included 5 patients, all female, with mean age 54 years [40–76 years]. The PHPT was in all cases revealed by acute pancreatitis (AP). This one was oedematous in four cases and severe in one case. It occurred twice in calcified chronic pancreatitis (CCP). There was hypercalcemia in all cases. The PHPT was associated with a high rate of parathyroid hormone in 4 cases. The secreting lesion was an adenoma in 5 cases. Two patients had in addition bilateral renal calcifications. The outcome was favorable in 4 patients among whom 3 have had parathyroid surgery. A death was noted by superinfection of necrosis in the case of severe AP. Conclusion . The occurrence of pancreatitis during hyperparathyroidism is rare. Normal or elevated calcemia during acute or chronic pancreatitis should always get attention.