Verruciform Xanthoma of the Oral Mucosa: A Series of Eight Typical and Three Anomalous Cases. (August 2019)

• Record Type: Journal Article
• Authors: Barrett, A. W.; Boyapati, R. P.; Bisase, B. S.; Norris, P. M.; Shelley, M. J.; Collyer, J.; Sneddon, K. J.; Gulati, A.
• Is Part Of: International journal of surgical pathology. Volume 27:Number 5(2019)
• Page Start: 492
• Page End: 498
• Publication Date: 2019-08
• Subjects: oral cavity -- verruciform xanthoma -- macrophages -- foam cells -- granular cells; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/1066896919827374
• Languages: English
• ISSNs: 1066-8969

Abstract

In this series, there are 8 typical verruciform xanthomas of the oral mucosa and 3 anomalies, 1 polypoid, 1 florid, and 1 carcinomatous. All were characterized by infiltrates of CD68-positive xanthomatous histiocytes in the lamina propria. The 11 patients comprised 6 men and 5 women (mean age = 54.5 years, range = 40-69). Both keratinized and nonkeratinized sites were affected. A history of lichenoid inflammation was recorded in 5 patients. The polypoid xanthoma presented in a woman aged 54 years as a polyp of the labial commissure. The florid lesion affected the dorsum of the tongue of a man aged 54 years and at 20 mm was the largest of the 11 lesions, but the only one with candidal infection. The squamous cell carcinoma manifested as a papilloverrucous hyperkeratosis of the palatal gingiva in a man aged 69 years. The latter 2 (and 1 "typical" verruciform xanthoma) required re-excision, but none has since recurred.