"On water" catalysis: an expeditious approach for the synthesis of quaternary centered 3-hydroxy-3-(nitromethyl)indolin-2-one derivatives. Issue 4 (23rd February 2015)

• Record Type: Journal Article
• Authors: SaiPrathima, Parvathaneni; Srinivas, Keesara; Mohan Rao, Mandapati
• Is Part Of: Green chemistry. Volume 17:Issue 4(2015)
• Page Start: 2339
• Page End: 2343
• Publication Date: 2015-02-23
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c4gc02203c
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : An efficient, eco-friendly "on water" method has been developed for the Henry reaction of isatins with nitromethane to afford 3-hydroxy-3-nitromethylindolin-2-ones. An enhancement in reaction rate was observed "on water" under mild and catalyst-free conditions. Abstract : A novel, efficient, eco-friendly "on water" method has been developed for the Henry reaction of isatins with nitromethane to afford 3-hydroxy-3-nitromethylindolin-2-ones. An enhancement in reaction rate was observed "on water" under mild and catalyst-free conditions. This reaction tolerated a wide range of substrates with good to excellent product yields and is even applicable at large scales. Moreover, this method is environmentally friendly as it reduces the waste generated by the use of toxic solvents.