Paraoxonase responses to exercise and niacin therapy in men with metabolic syndrome. (January 2015)

• Record Type: Journal Article
• Authors: Taylor, James Kyle; Plaisance, Eric P.; Mahurin, A. Jack; Mestek, Michael L.; Moncada-Jimenez, Jose; Grandjean, Peter W.
• Is Part Of: Redox report. Volume 20:Number 1(2015)
• Page Start: 42
• Page End: 48
• Publication Date: 2015-01
• Subjects: Paraoxonase -- Lipoprotein particle size -- Lipid oxidation -- Exercise -- Niacin; Free radicals (Chemistry) -- Pathophysiology -- Periodicals; Oxidation, Physiological -- Periodicals; 541.224
• DOI: 10.1179/1351000214Y.0000000103
• Languages: English
• ISSNs: 1351-0002

Abstract

Abstract : Our purpose was to characterize changes in paraoxonase 1 (PON1) activity and concentration after single aerobic exercise sessions conducted before and after 6 weeks of niacin therapy in men with metabolic syndrome (MetS). Twelve men with MetS expended 500 kcal by walking at 65% of VO2max before and after a 6-week regimen of niacin. Niacin doses were titrated by 500 mg/week from 500 to 1500 mg/day and maintained at 1500 mg/day for the last 4 weeks. Fasting blood samples were collected before and 24 hours after each exercise session and analyzed for PON1 activity, PON1 concentration, myeloperoxidase (MPO), apolipoprotein A1, oxidized low-density lipoprotein (oLDL), lipoprotein particle sizes and concentrations. PON1 activity, PON1 concentration, MPO, and oLDL were unaltered following the independent effects of exercise and niacin ( P > 0.05 for all). High-density lipoprotein particle size decreased by 3% ( P = 0.040) and concentrations of small very low-density lipoprotein increased ( P = 0.016) following exercise. PON1 activity increased 6.1% ( P = 0.037) and PON1 concentrations increased 11.3% ( P = 0.015) with the combination of exercise and niacin. Exercise and niacin works synergistically to increase PON1 activity and concentration with little or no changes in lipoproteins or markers of lipid oxidation.