Corticolimbic connectivity as a possible biomarker for bipolar disorder. (June 2014)

• Record Type: Journal Article
• Authors: Vai, Benedetta; Bollettini, Irene; Benedetti, Francesco
• Is Part Of: Expert review of neurotherapeutics. Volume 14:Number 6(2014)
• Page Start: 631
• Page End: 650
• Publication Date: 2014-06
• Subjects: biomarker -- bipolar disorder -- connectivity -- corticolimbic circuitry -- development; Neuropharmacology -- Periodicals; 615.7805
• DOI: 10.1586/14737175.2014.915744
• Languages: English
• ISSNs: 1473-7175

Abstract

Abstract : Bipolar disorder is a severe, disabling and life-threatening illness, which affects nearly 2% of the general population. The identification of reliable and objective biomarkers may aid early diagnosis and optimize treatment efficacy. Through a careful overview of the neuroimaging studies which investigated the structural, functional, and effective connectivity in bipolar disorder, we explored the role of a disconnected cortico-limbic circuitry in the development and maintenance of the disorder. This review offers perspectives and suggestions for future research, in order to propose the corticolimbic disconnection as a neurobiological underpinning and biomarker for bipolar psychopathology.