Piptolinic acids F–J, five new lanostane-type triterpenoids from Piptoporus betulinus. Issue 21 (2nd November 2019)

• Record Type: Journal Article
• Authors: Khalilov, Qosimjon; Li, Liya; Liu, Yushuang; Tohtahon, Zeynep; Chen, Xiaoyu; Aisa, Haji Akber; Yuan, Tao
• Is Part Of: Natural product research. Volume 33:Issue 21(2019)
• Page Start: 3044
• Page End: 3051
• Publication Date: 2019-11-02
• Subjects: Piptoporus betulinus -- polyporaceae -- lanostane triterpenoid -- cytotoxicity -- A-375 -- 786-O; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1516218
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Five new lanostane-type triterpenoids, named piptolinic acids F − J (1 –5 ), as well as seven known analogues (6 –12 ), were isolated from methanolic extract of the fruiting bodies of Piptoporus betulinus . Compounds1 –4 were 24-methyl-lanostane triterpenoids, while compound5 was a 3, 4- seco -lanostane derivative. Their structures were established on the basis of extensive spectroscopic analysis (1D, 2D NMR, and HRESIMS). Cytotoxicity evaluation indicated that compound6 exhibited moderate cytotoxic activity against human melanoma cell line A-375 (IC50 = 42.8 μM) and human renal carcinoma cell line 786-O (IC50 = 56.5 μM). Graphical Abstract: