Tests for homogeneity of risk differences in stratified design with correlated bilateral data. Issue 14 (26th October 2019)

• Record Type: Journal Article
• Authors: Qiu, Shi-Fang; Guo, Li-Xuan; Zou, G. Y.; Yu, Dan
• Is Part Of: Journal of applied statistics. Volume 46:Issue 14(2019)
• Page Start: 2491
• Page End: 2513
• Publication Date: 2019-10-26
• Subjects: Correlated bilateral data -- homogeneity testing -- modified score test -- sample size determination -- stratified design; Statistics -- Periodicals; 519.5
• DOI: 10.1080/02664763.2019.1601162
• Languages: English
• ISSNs: 0266-4763

Abstract

ABSTRACT: Correlated bilateral data arise from stratified studies involving paired body organs in a subject. When it is desirable to conduct inference on the scale of risk difference, one needs first to assess the assumption of homogeneity in risk differences across strata. For testing homogeneity of risk differences, we herein propose eight methods derived respectively from weighted-least-squares (WLS), the Mantel-Haenszel (MH) estimator, the WLS method in combination with inverse hyperbolic tangent transformation, and the test statistics based on their log-transformation, the modified Score test statistic and Likelihood ratio test statistic. Simulation results showed that four of the tests perform well in general, with the tests based on the WLS method and inverse hyperbolic tangent transformation always performing satisfactorily even under small sample size designs. The methods are illustrated with a dataset.