Modification of collagen-chitosan membrane by oxidation sodium alginate and in vivo/ in vitro evaluation for wound dressing application. Issue 7 (3rd October 2019)

• Record Type: Journal Article
• Authors: Yang, Changkai; Dan, Nianhua; You, Weiting; Huang, Yanping; Chen, Yining; Yu, Guofei; Dan, Weihua; Wen, Huitao
• Is Part Of: International journal of polymer analysis and characterization. Volume 24:Issue 7(2019)
• Page Start: 619
• Page End: 629
• Publication Date: 2019-10-03
• Subjects: Collagen -- chitosan -- oxidation sodium alginate -- cross-linking -- in vivo/in vitro -- wound dressing; Polymers -- Analysis -- Periodicals; 547.705
• DOI: 10.1080/1023666X.2019.1648637
• Languages: English
• ISSNs: 1023-666X

Abstract

Abstract: Collagen-chitosan (COL-CS) membranes materials without a cross-linking agent have poor mechanical properties. In this paper, COL-CS membranes were modified by a novel naturally-derived crosslinker, alginate dialdehyde (ADA) with different oxidation degree, and the COL-CS-ADA films were obtained. COL-CS-ADA films were characterized by Fourier transform attenuation total reflection infrared spectroscopy (ATR-FTIR), differential calorimetric scanning (DSC), thermogravimetric analysis (TG), tensile testing, and cross-link density testing. The modification of ADA exhibited positive effects on mechanical properties, the thermal stability of COL-CS membranes. The cross-linking degree between ADA and COL-CS membranes increased significantly with an increase in the oxidation degree. COL-CS-ADA films showed no cytotoxicity toward L929 fibroblasts and had good biocompatibility. The animal experiments showed that COL-CS-ADA film could promote wound healing.