New benzyl-aporphine alkaloids from Thalictrum cultratum. Issue 21 (2nd November 2019)

• Record Type: Journal Article
• Authors: Kang, Wenjia; Li, Jianyong; Li, Dahong; Li, Zhanlin; Chen, Shengshuang; Hua, Huiming; Bai, Jiao
• Is Part Of: Natural product research. Volume 33:Issue 21(2019)
• Page Start: 3176
• Page End: 3179
• Publication Date: 2019-11-02
• Subjects: Thalictrum cultratum -- alkaloid -- benzyl-aporphine dimmer -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1523160
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new rare benzyl-aporphine alkaloids, thaliculine (1 ) and 6a, 7-dehydrothaliculine (2 ), were isolated from the roots of Thalictrum cultratum Wall. Their structures were determined based on spectroscopic analysis including 1D, 2D NMR, and HR-ESI-MS. The stereochemistry of1 was assigned by ECD spectroscopy. Compound1 exhibited weak cytotoxicity against HL-60 cell line with IC50 value of 31.40 μM. Abstract :