Interleukin-6 Receptor (IL-6R) Expression in Human Gastric Carcinoma and its Clinical Significance. (9th August 2019)

• Record Type: Journal Article
• Authors: Simondurairaj, C.; Krishnakumar, R.; Sundaram, Sandhya; Venkatraman, Ganesh
• Is Part Of: Cancer investigation. Volume 37:Number 7(2019)
• Page Start: 293
• Page End: 298
• Publication Date: 2019-08-09
• Subjects: Cytokine -- gastric cancer -- immunohistochemistry -- Interleukin-6 receptor -- prognostic marker; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2019.1638395
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: The aim of the study is to analyse the expression of Interleukin-6 receptor in different human gastric tissue and to correlate with the clinicopathological features of the patients. Immunohistochemistry was done against the IL-6R antibody and the Q-score was calculated from the staining pattern. Higher Q-scores were observed in tumour cells than the adjacent normal cells which were statistically significant. We also observed a significant correlation between the expressions of IL-6R and the clinicopathological features These findings suggest that IL-6R may represent as a therapeutic target for gastric carcinoma and serve as a prognostic indicator, as well.