Zinc(II)‐Dipicolylamine Coordination Nanotheranostics: Toward Synergistic Nanomedicine by Combined Photo/Gene Therapy. Issue 1 (5th December 2018)

• Record Type: Journal Article
• Authors: Chu, Chengchao; Ren, En; Zhang, Yunming; Yu, Jingwen; Lin, Huirong; Pang, Xin; Zhang, Yang; Liu, Heng; Qin, Zainen; Cheng, Yi; Wang, Xiaoyong; Li, Wei; Kong, Xiangjian; Chen, Xiaoyuan; Liu, Gang
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 1(2018)
• Page Start: 269
• Page End: 272
• Publication Date: 2018-12-05
• Subjects: gene therapy -- indocyanine green -- metal–organic nanostructures -- phototherapy -- ZnII-dipicolylamine; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201812482
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: We report the rational design of coordination‐driven self‐assembly metal–organic nanostructures for multifunctional nanotheranostics. Zinc(II) coordination‐based nano‐formulations capable of loading indocyanine green (ICG) and therapeutic genes were prepared to achieve a fluorescence/photoacoustic imaging‐guided combination photo/gene therapy strategy. We showed the enhanced theranostic capability of zinc(II)‐dipicolylamine‐assisted assembly of ICG, as well as simultaneous targeted gene delivery in an experimental mouse model of cancer. Such a co‐assembly strategy provides a facile way to achieve combined therapeutic functions for personalized nanomedicine. Abstract : A simple but powerful coordination : A new zinc(II)‐dipicolylamine‐based nano‐formulation capable of loading indocyanine green (ICG) and therapeutic genes is presented. By using this platform, fluorescence/photoacoustic imaging‐guided photo/gene combination therapy was achieved.