A mitochondria-targeted iridium(iii)-based photoacid generator induces dual-mode photodynamic damage within cancer cells. Issue 70 (14th August 2019)

• Record Type: Journal Article
• Authors: He, Liang; Zhang, Ming-Fang; Pan, Zheng-Yin; Wang, Kang-Nan; Zhao, Zi-Jian; Li, Yi; Mao, Zong-Wan
• Is Part Of: Chemical communications. Volume 55:Issue 70(2019)
• Page Start: 10472
• Page End: 10475
• Publication Date: 2019-08-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc04871e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An Ir(iii )-based photoacid generator was developed as a dual-mode photodynamic therapy agent to kill cancer cells under hypoxic conditions. Abstract : A mitochondria-targeted photodynamic therapy (PDT) agent was designed and synthesized. Upon light irradiation, it can produce photoacid and its photolysis products can further sensitize 1 O2 generation, causing dual-mode (oxygen-independent and oxygen-dependent) photodynamic damage in mitochondria and killing cancer cells effectively even under hypoxic conditions.