Transforming stealthy to sticky nanocarriers: a potential application for tumor therapy. (2nd July 2019)

• Record Type: Journal Article
• Authors: Gafur, Alidha; Kristi, Natalia; Maruf, Ali; Wang, Guixue; Ye, Zhiyi
• Is Part Of: Biomaterials science. Volume 7:Number 9(2019)
• Page Start: 3581
• Page End: 3593
• Publication Date: 2019-07-02
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/c9bm00724e
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : Recently, chameleon-like drug delivery systems have shown great potential in achieving simultaneous stealthy and sticky surfaces of nanocarriers to target/retarget tumors. Abstract : Nanomedicine has shown remarkable progress in preclinical studies of tumor treatment. Over the past decade, scientists have developed various nanocarriers (NCs) for delivering drugs into the tumor area. However, the average amount of accumulated drugs in tumor sites is far from satisfactory. This limitation is strongly related to the corona formation during blood circulation. To overcome this issue, NCs should be designed to become highly stealthy by modifying their surface charge. However, at the same time, stealthy effects not only prevent protein formation but also alleviate the cellular uptake of NCs. Therefore, it is necessary to develop NCs with switchable properties, which are stealthy in the circulation system and sticky when arriving at tumor sites. In this review, we discuss the recent strategies to develop passive and active charge-switchable NCs, known as chameleon-like drug delivery systems, which can reversibly transform their surface from stealthy to sticky and have various designs.