Quantification of CYFRA 21-1 and a CYFRA 21-1–anti-CYFRA 21-1 autoantibody immune complex for detection of early stage lung cancer. Issue 68 (22nd July 2019)

• Record Type: Journal Article
• Authors: Song, Keum-Soo; Nimse, Satish Balasaheb; Warkad, Shrikant Dashrath; Oh, Ae-Chin; Kim, Taisun; Hong, Young Jun
• Is Part Of: Chemical communications. Volume 55:Issue 68(2019)
• Page Start: 10060
• Page End: 10063
• Publication Date: 2019-07-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc03620b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Population-based screening of stage 0–I lung cancer is crucial for saving lives. The CIC/CYFRA 21-1 ratio allows the detection of stage I lung cancer with 76.0% sensitivity and 87.5% specificity. Abstract : Population-based screening of stage 0–I lung cancer is crucial to save lives. In this article, we describe the development of a method for the detection of a CYFRA 21-1-autoantibody complex and CYFRA 21-1 in plasma samples. The CIC/CYFRA 21-1 ratio allows the detection of stage I–IV lung cancer with 76.0% sensitivity and 87.5% specificity.