Multi-approach cysteine detection based on supramolecular transformation induced by G-quadruplexes. Issue 33 (30th July 2019)

• Record Type: Journal Article
• Authors: Yang, Dawei; Chen, Hongbo; Li, Qian; Zhang, Xiufeng; Sun, Hongxia; Tang, Yalin
• Is Part Of: Analytical methods. Volume 11:Issue 33(2019)
• Page Start: 4249
• Page End: 4253
• Publication Date: 2019-07-30
• Subjects: Chemistry, Analytic -- Periodicals; Analytical biochemistry -- Periodicals; Chemical laboratories -- Standards -- Periodicals; 543.1905
• DOI: 10.1039/c9ay01323g
• Languages: English
• ISSNs: 1759-9660

Abstract

Abstract : Cysteine detection based on supramolecular transformation induced by G-quadruplexes. Abstract : Development of a cysteine (Cys) detection probe is of significant importance in clinical diagnosis. Herein, a colorimetric, chiral and fluorometric multi-approach detection probe for Cys has been designed. This probe utilized G-quadruplexes as a template to regulate the supramolecular transformation of a cyanine dye and achieve label-free and highly selective detection of Cys. Its successful use in urinary Cys measurement demonstrates good promise for practical applications.