Visualizing biofilm by targeting eDNA with long wavelength probe CDr15. (22nd July 2019)

• Record Type: Journal Article
• Authors: Kwon, Haw-Young; Kim, Jun-Young; Liu, Xiao; Lee, Jung Yeol; Yam, Joey Kuok Hoong; Dahl Hultqvist, Louise; Xu, Wang; Rybtke, Morten; Tolker-Nielsen, Tim; Heo, Wooseok; Kim, Jong-Jin; Kang, Nam-Young; Joo, Taiha; Yang, Liang; Park, Sung-Jin; Givskov, Michael; Chang, Young-Tae
• Is Part Of: Biomaterials science. Volume 7:Number 9(2019)
• Page Start: 3594
• Page End: 3598
• Publication Date: 2019-07-22
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/c9bm00152b
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : We developed a small molecule CDr15, which has eDNA selectivity of bacterial biofilm. Abstract : Detection of the biofilm of bacteria would be a counter strategy to detect hidden bacteria in their camouflage. Through unbiased screening of bacteria biofilm, we discovered a long wavelength probe CDr15 with extracellular DNA as the molecular target. CDr15 revealed a real-time geometric distribution of eDNA in a 3D bacterial colony.