Diastereoselective access to 2-aminoindanones via the rhodium(ii)-catalyzed tandem reaction involving O–H insertion and Michael addition. Issue 17 (22nd July 2019)

• Record Type: Journal Article
• Authors: Xing, Siyang; Xia, Hanyu; Wang, Xin; Wu, Die; Xu, Xinrui; Su, Yunran; Wang, Kui; Zhu, Bolin; Guo, Junshuo
• Is Part Of: Organic chemistry frontiers. Volume 6:Issue 17(2019)
• Page Start: 3121
• Page End: 3126
• Publication Date: 2019-07-22
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c9qo00765b
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A rhodium(ii )-catalyzed tandem reaction involving O–H insertion of N -sulfonyl 1, 2, 3-triazoles and Michael addition has been described. A series of 2-amino-1-indanones were afforded in acceptable to good yields with high diastereoselectivities. Abstract : A rhodium(ii )-catalyzed tandem reaction involving the O–H insertion of N -sulfonyl 1, 2, 3-triazoles with H2 O and Michael addition has been developed for the construction of 2-amino-1-indanones by the formation of one new CO bond and one new C–C bond. The notable features of the strategy include acceptable to good yields, high diastereoselectivities, and mild conditions. It provides a good choice for the construction of libraries of highly functionalized indanone compounds.