Human brain arteriovenous malformation: an analysis of differential expressed genes. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Liu, Xing; Meng, Guolu; Yu, Tengfei; Lin, Xiangjiang; Zhang, Liwei; Fei, Xiaobin; Zhang, Junting; Wu, Zhen; Deng, Shengze; Ren, Shunlin; Wang, Shuo; Zhao, Jizong
• Is Part Of: Chinese neurosurgical journal. Volume 2:Issue 1(2016)
• Page Start: 1
• Page End: 6
• Publication Date: 2016-12
• Subjects: Brain arteriovenous malformations -- Gene microarray technique -- VCAN -- SPARK -- ARHGAP18 -- MAPK pathway; Nervous system -- Surgery -- Periodicals; Neurosciences -- Periodicals; 617.48005
• DOI: 10.1186/s41016-016-0061-4
• Languages: English
• ISSNs: 2057-4967

Abstract

Abstract Background Much still remains unknown about the pathogenesis of brain arteriovenous malformations (AVMs). Previous studies have revealed the abnormal expression of various angiogenesis-related genes in AVMs. To further understand this disease, we sought to identify genes differently expressed in AVMs by means of the gene microarray technique. Methods Nine AVMs specimen and nine samples of normal vessels are collected. Total RNA isolated from these specimen is hybridized with Oligonucleotide array and gene analysis was conducted. Analyzing data with the help of significance analysis of microarrays (SAM) and a free web-based molecular annotation system 3.0 (MAS 3.0). Results The SAM method identify 37 gene significantly up-regulated and 10 genes down-regulated in AVMs. Conclusions Among those genes, VACN, SPARK and ARHGAP18 seem to play a facilitating role during the genesis of AVMs. Multiple pathways, as MAPK pathway, may also be involved.