Community-acquired meningitis caused by a CG86 hypervirulent Klebsiella pneumoniae strain: first case report in the Caribbean. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Melot, Bénédicte; Brisse, Sylvain; Breurec, Sébastien; Passet, Virginie; Malpote, Edith; Lamaury, Isabelle; Thiery, Guillaume; Hoen, Bruno
• Is Part Of: BMC infectious diseases. Volume 16:Issue 1(2016)
• Page Start: 1
• Page End: 3
• Publication Date: 2016-12
• Subjects: Community acquired meningitis -- ST86 hypervirulent Klebsiella pneumoniae strain -- Caribbean; Communicable diseases -- Periodicals; Sexually Transmitted Diseases -- Periodicals; 616.905
• DOI: 10.1186/s12879-016-2065-2
• Languages: English
• ISSNs: 1471-2334

Abstract

Abstract Background Community-acquired bacterial meningitis due toKlebsiella pneumoniae has mainly been described in Southeast Asia and has a poor prognosis. Severe invasive infections caused byK. pneumoniae, including meningitis, are often due to hypervirulent strains(hvKP), which are characterized by capsular serotypes K1 and K2, a gene responsible for hypermucoviscosity, and the cluster for synthesis of the siderophore aerobactin. Case presentation A 55 year old man with a history of essential hypertension, benign prostate hyperplasia, hyperlipidemia, obstructive sleep apnea, and chronic alcoholism was admitted for meningitis due toKlebsiella pneumoniae with a wild-type susceptibility profile. Its genomic features were consistent with a capsular K2 strain belonging to clonal group 86 (CG86) displaying the large virulence ofKlebsiella plasmid (pLVPK) with heavy metal resistance gene clusters, aerobactin, rmpA. Conclusion This is the first case of community-acquired meningitis caused by a hypervirulent strain ofhvKP ever reported in the Caribbean.