The association of thyroid stimulating hormone levels and intrauterine insemination outcomes of euthyroid unexplained subfertile couples. (September 2019)

• Record Type: Journal Article
• Authors: Turgay, Batuhan; Şükür, Yavuz Emre; Ulubaşoğlu, Hasan; Sönmezer, Murat; Berker, Bülent; Atabekoğlu, Cem; Aytaç, Ruşen; Özmen, Batuhan
• Is Part Of: European journal of obstetrics, gynecology, and reproductive biology. Volume 240(2019)
• Page Start: 99
• Page End: 102
• Publication Date: 2019-09
• Subjects: Infertility -- Intrauterine insemination -- Thyroid antibody -- Thyroid stimulating hormone -- Assisted reproductive technology; Obstetrics -- Periodicals; Gynecology -- Periodicals; Reproductive health -- Periodicals; Gynecology -- Periodicals; Obstetrics -- Periodicals; Reproduction -- Periodicals; Obstétrique -- Périodiques; Gynécologie -- Périodiques; Reproduction -- Périodiques; Verloskunde; Gynaecologie; Voortplanting (biologie); Gynecology; Obstetrics; Reproduction; Electronic journals; Periodicals; Electronic journals; 618.05
• DOI: 10.1016/j.ejogrb.2019.06.022
• Languages: English
• ISSNs: 0301-2115

Abstract

Abstract: Objective: To investigate the effect of different TSH (0.5–2.49 mIU/L and 2.5–4.5 mIU/L) levels on intrauterine insemination (IUI) outcomes of euthyroid unexplained subfertile patients who are negative for thyroid antibodies. Study design: In this retrospective cohort study, data of euthyroid subfertile patients who underwent IUI due to unexplained infertility at a university-based infertility clinic between January 2013 and December 2014 were reviewed. A total of 156 patients of them were categorized into two groups according to pre-conceptional TSH levels. The first study group consisted of patients with serum TSH levels 0.5–2.49 mIU/L and the second study group consisted of patients with serum TSH levels 2.5–4.5 mIU/L. The primary outcome measure was live birth rate. Results: Demographics and cycle characteristics of the study groups were similar. There were no statistically significant differences between the study groups regarding main outcome measures (live birth rate, P = 0.82; clinical pregnancy rate, P = 0.64; miscarriage rate, P = 0.57). Conclusion: Pre-conceptional TSH levels ranging between 0.5–4.5 mU/L does not appear to have a significant effect on IUI outcome of euthyroid women who are negative for thyroid antibodies.