Benefits of pre-labyrinthectomy intratympanic gentamicin: contralateral vestibular responses. Issue 8 (16th July 2019)

• Record Type: Journal Article
• Authors: Amiraraghi, N; Gaggini, M; Crowther, J A; Locke, R; Taylor, W; Kontorinis, G
• Is Part Of: Journal of laryngology & otology. Volume 133:Issue 8(2019)
• Page Start: 668
• Page End: 673
• Publication Date: 2019-07-16
• Subjects: Dizziness, -- Gentamicin, -- Labyrinth, -- Vestibular Schwannoma, -- Vestibular Function Tests; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1017/S0022215119001002
• Languages: English
• ISSNs: 0022-2151

Abstract

Abstract: Objective: To determine the impact of pre-operative intratympanic gentamicin injection on the recovery of patients undergoing translabyrinthine resection of vestibular schwannomas. Methods: This prospective, case–control pilot study included eight patients undergoing surgical labyrinthectomy, divided into two groups: four patients who received pre-operative intratympanic gentamicin and four patients who did not. The post-operative six-canal video head impulse test responses and length of in-patient stay were assessed. Results: The average length of stay was shorter for patients who received intratympanic gentamicin (6.75 days; range, 6–7 days) than for those who did not (9.5 days; range, 8–11 days) ( p = 0.0073). Additionally, the gentamicin group had normal post-operative video head impulse test responses in the contralateral ear, while the non-gentamicin group did not. Conclusion: Pre-operative intratympanic gentamicin improves the recovery following vestibular schwannoma resection, eliminating, as per the video head impulse test, the impact of labyrinthectomy on the contralateral labyrinth.