Chemically Fueled Dissipative Self‐Assembly that Exploits Cooperative Catalysis. Issue 1 (4th December 2018)

• Record Type: Journal Article
• Authors: Bal, Subhajit; Das, Krishnendu; Ahmed, Sahnawaz; Das, Dibyendu
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 1(2018)
• Page Start: 244
• Page End: 247
• Publication Date: 2018-12-04
• Subjects: catalysis -- cooperative effects -- dissipative self-assembly -- gels -- systems chemistry; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201811749
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: In living systems, dissipative processes are driven by the endergonic hydrolysis of chemical fuels such as nucleoside triphosphates. Now, through a simple model system, a transient self‐assembled state is realized by utilizing the catalytic effect of histidine on the formation and breaking of ester bonds. First, histidine facilitates the ester bond formation, which then rapidly co‐assembles to form a self‐supporting gel. An out‐of‐equilibrium state is realized owing to the cooperative catalysis by the proximal histidines in the assembled state, driving the second pathway and resulting in disassembly to sol. Cooperative effects that use the dual role of imidazoles as nucleophile and as proton donor is utilized to achieve transient assemblies. This simple system mimics the structural journey seen in microtubule formation where the substrate GTP facilitates the non‐covalent assembly and triggers a cooperative catalytic process, leading to substrate hydrolysis and subsequent disassembly. Abstract : Self‐driving : A simple fuel‐driven self‐assembled system is demonstrated that achieves an out‐of‐equilibrium state by dissipating energy from the assembled structures. This occurs by utilizing cooperative effects of the proximally located histidines, which catalyze the hydrolysis of ester bonds of the lipid‐tailed amphiphile.