Transition‐Metal‐Catalyzed Selective Functionalization of C(sp3)−H Bonds in Natural Products. Issue 16 (14th February 2018)

• Record Type: Journal Article
• Authors: Karimov, Rashad R.; Hartwig, John F.
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 16(2018)
• Page Start: 4234
• Page End: 4241
• Publication Date: 2018-02-14
• Subjects: amination -- catalysis -- C−H bond functionalization -- oxidation -- regioselectivity; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201710330
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Direct functionalization of natural products is important for studying the structure–activity and structure–property relationships of these molecules. Recent advances in the transition‐metal‐catalyzed functionalization of C(sp 3 )−H bonds, the most abundant yet inert bonds in natural products, have allowed natural product derivatives to be created selectively. Strategies to achieve such transformation are reviewed. Abstract : Direct derivatization : Direct functionalization of natural products is important for studying their structure–activity and structure–property relationships. Recent advances in the transition‐metal‐catalyzed functionalization of C(sp 3 )−H bonds have shown that natural product derivatives can be selectively produced. Strategies for achieving such transformations are discussed.