N‐Bromosuccinimide Promoted Direct Thiolation of Imidazoheteroaryl C‐H bonds with Disulfides. Issue 4 (8th February 2017)

• Record Type: Journal Article
• Authors: Maddi, Raghavender Reddy; Shirsat, Prashishkumar K.; Kumar, Santosh; Meshram, H. M.
• Is Part Of: ChemistrySelect. Volume 2:Issue 4(2017)
• Page Start: 1544
• Page End: 1547
• Publication Date: 2017-02-08
• Subjects: Disulfides -- Imidazopyridines -- Low temperature reaction -- N-Bromosuccinimide -- Sulfenylation; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201601460
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A one‐pot protocol has been demonstrated for the regioselective sulfenylation of imidazoheterocycles with disulfides. In this method, thiols are converted to sulfenyl bromides and reacted with 2‐phenylimidazo [1, 2‐a] pyridines. This simple procedure is highly capable for sulfenylation with readily available starting materials in good to excellent yields under transition metal and base free conditions. Abstract : A straightforward methodology for the synthesis of sulfenyl imidazoheterocycles from easily available disulfides with imidazoheterocyles through NBS at −10 °C for 2 hours. In this electron donating and withdrawing containing disulfides as well as imidazo heterocyles were gave good to high yields respectively. And we screened the catalyst along with NBS we also tried with NCS no product formed, and with NIS found moderate yields. We varied the temperature the best condition for the reaction is −10 °C.