Intermolecular Multiple Dehydrogenative Cross‐Couplings of Ketones with Boronic Acids and Amines via Copper Catalysis. Issue 16 (12th July 2019)

• Record Type: Journal Article
• Authors: Wang, Tianzhang; Chen, Guowei; Lu, Yu‐Jing; Chen, Qian; Huo, Yanping; Li, Xianwei
• Is Part Of: Advanced synthesis & catalysis. Volume 361:Issue 16(2019)
• Page Start: 3886
• Page End: 3892
• Publication Date: 2019-07-12
• Subjects: Intermolecular multiple dehydrogenative couplings -- α, β-unsaturated ketones -- enaminones -- meta-substituted phenols -- copper catalysis; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201900419
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An efficient and versatile oxidative coupling reaction was developed for the synthesis of valuable β‐functionalized unsaturated ketones and meta ‐substituted phenols. In the case of intramolecular reactions, achieving rapid molecular complexity through multiple dehydrogenative couplings is already a well‐established strategy. Herein, we report an intermolecular multiple dehydrogenative coupling between ketones and nucleophilic amines or boronic acids using inexpensive copper(I) oxide as a catalyst. This method provides a facile access to highly desirable chemical products such as α, β‐unsaturated ketones, enaminones, and synthetically relevant meta ‐substituted phenols. Abstract :