Intracellular target delivery of 10-hydroxycamptothecin with solid lipid nanoparticles against multidrug resistance. (21st October 2015)

• Record Type: Journal Article
• Authors: Liu, Min; Chen, Didi; Wang, Chenxu; Chen, Xunhu; Wen, Zhili; Cao, Yu; He, Hongxuan
• Is Part Of: Journal of drug targeting. Volume 23:Number 9(2015)
• Page Start: 800
• Page End: 805
• Publication Date: 2015-10-21
• Subjects: 10-Hydroxycamptothecin -- multidrug resistance -- solid lipid nanoparticles; Drug delivery systems -- Periodicals; Drug Delivery Systems; Vehicles; Drug Administration Routes; Drug Evaluation; 615.7
• DOI: 10.3109/1061186X.2015.1020427
• Languages: English
• ISSNs: 1061-186X

Abstract

Abstract: The main objective of this study was to design a suitable drug delivery system for 10-hydroxycamptothecin (HCPT). In this study, HCPT-loaded solid lipid nanoparticle (HCPT-loaded SLN) was successfully prepared. The HCPT-loaded SLN was characterized by size, entrapment efficiency and drug release manner. The cytotoxicity of HCPT-loaded SLN was assessed in vitro using HepG2/HCPT cells and in vivo utilizing human tumor xenograft nude mouse model. HCPT-loaded SLN indicated the ability to target HepG2/HCPT cells and accumulated higher drug content in HepG2/HCPT cells. HCPT-loaded SLN enhanced the cytotoxicity of HCPT in a concentration-dependent manner. Based on these results, HCPT-loaded SLN suggested being a promising vehicle for liver-targeted drug delivery. Moreover, it can be of clinical interest to overcome multidrug resistance (MDR) effectively.