A biochemical and immunohistochemical study of the protective effects of carnosine for carbon tetrachloride induced liver injury in rats. (17th November 2015)

• Record Type: Journal Article
• Authors: Kuloglu, N; Sönmez, MF
• Is Part Of: Biotechnic & histochemistry. Volume 90:Number 8(2015)
• Page Start: 608
• Page End: 614
• Publication Date: 2015-11-17
• Subjects: carbon tetrachloride -- carnosine -- HSP-70 -- liver -- rat; Histochemistry -- Periodicals; Stains and staining (Microscopy) -- Periodicals; Biotechnology -- Periodicals; 572
• DOI: 10.3109/10520295.2015.1044565
• Languages: English
• ISSNs: 1052-0295

Abstract

Abstract : We investigated the protective effect of carnosine on carbon tetrachloride-induced liver tissue damage. Thirty-two adult male rats were divided into four equal groups. Group 1 was the untreated control, group 2 was injected with 0.2 ml/kg/day carbon tetrachloride, group 3 was injected with with 0.2 ml/kg/day carbon tetrachloride plus 200 mg/kg/day carnosine, and group 4 was injected with 200 mg/kg/day carnosine. Increased serum alanine amino transferase and aspartate amino transferase levels, liver malondialdehyde levels, HSP-70 expression and steatosis were observed following treatment with carbon tetrachloride. Carbon tetrachloride caused severe biochemical and histopathological changes in liver tissue and treatment with carnosine partially prevented the damage. HSP-70 may help control liver damage.