Heart and Brain Interactions – the Akershus Cardiac Examination (ACE) 1950 Study Design. (2nd November 2015)

• Record Type: Journal Article
• Authors: Berge, Trygve; Vigen, Thea; Pervez, Mohammad Osman; Ihle-Hansen, Haakon; Lyngbakken, Magnus Nakrem; Omland, Torbjørn; Smith, Pål; Steine, Kjetil; Røsjø, Helge; Tveit, Arnljot
• Is Part Of: Scandinavian cardiovascular journal. Volume 49:Number 6(2015:Dec.)
• Page Start: 308
• Page End: 315
• Publication Date: 2015-11-02
• Subjects: cardiovascular epidemiology -- cerebrovascular epidemiology -- cohort study -- atrial fibrillation -- stroke -- heart failure -- cognitive function; Cardiovascular system -- Diseases -- Periodicals; 617.41
• DOI: 10.3109/14017431.2015.1086813
• Languages: English
• ISSNs: 1401-7431

Abstract

Abstract>: Objectives. The aim of the Akershus Cardiac Examination (ACE) 1950 Study is to investigate the development and progression of cardiovascular and cerebrovascular disease (CVD/CeVD) in an extensively characterized age cohort of middle-aged subjects with longitudinal long-term follow-up. Design. The ACE 1950 Study is a prospective, population-based, age-cohort study of all men and women born in 1950 in Akershus County, Norway. The study involves a comprehensive baseline examination, especially for CVD/CeVD, including advanced ultrasound imaging and biobanking ("deep phenotyping"). We expect to obtain an inclusion rate of > 60% from the total study population of 5, 827 eligible subjects. Enrollment will be completed during 2015. Conclusions. The ACE 1950 Study will have potential to generate new and relevant insight into identification of subclinical disease progression. Extensive phenotyping will enable identification of novel disease markers and mechanisms for subclinical disease, which can prove important for future disease prevention.