Comparison of the electrospray ionization (ESI) responses of penicillins with ESI responses of their methanolysis products. Issue 4 (August 2019)

• Record Type: Journal Article
• Authors: Podniesińska, Lidia; Frański, Rafał; Frańska, Magdalena
• Is Part Of: European journal of mass spectrometry. Volume 25:Issue 4(2019)
• Page Start: 357
• Page End: 361
• Publication Date: 2019-08
• Subjects: β-Lactam antibiotic -- penicillin G -- ampicillin -- carbenicillin -- methanolysis -- electrospray ionization -- mass spectrometry -- liquid chromatography; Mass spectrometry -- Periodicals; Mass Spectrometry; Mass spectrometry; Periodicals; Periodicals; 543.6505
• DOI: 10.1177/1469066718820434
• Languages: English
• ISSNs: 1469-0667

Abstract

The electrospray ionization (ESI) responses, defined as the area of chromatographic peak of ion [M +H] + obtained upon HPLC/ESI-MS analysis, of three β-lactam antibiotics, namely penicillin G, ampicillin and carbenicillin have been compared with the ESI responses of their methanolysis products. It has been found that methanolyzed penicillin G has much higher ESI response than the penicillin G. Methanolyzed ampicillin also has higher ESI response than ampicillin; however, the effect is less pronounced than for penicillin. Methanolyzed carbenicillin does not have pronouncedly higher ESI response than carbenicillin.