Ovarian stimulation for oocyte cryopreservation for prevention of age-related fertility loss: one in five is a low responder. (3rd October 2015)

• Record Type: Journal Article
• Authors: Tsafrir, Avi; Haimov-Kochman, Ronit; Margalioth, Ehud J.; Eldar-Geva, Talia; Gal, Michael; Bdolah, Yuval; Imbar, Tal; Hurwitz, Arye; Ben-Chetrit, Avraham; Goldberg, Doron
• Is Part Of: Gynecological endocrinology. Volume 31:Number 10(2015:Oct.)
• Page Start: 779
• Page End: 782
• Publication Date: 2015-10-03
• Subjects: Age-related infertility -- controlled ovarian stimulation -- oocyte cryopreservation -- social egg freezing; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.3109/09513590.2015.1062859
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Oocyte cryopreservation for age-related fertility loss is gaining interest considering the tendency to postpone motherhood in many societies. Little is currently known about the actual efficiency of this approach. We aimed to explore ovarian response of presumably fertile women undergoing in vitro fertilization for this indication. A total of 105 women underwent 151 stimulation cycles at mean age 37.7 ± 2.4. None had known infertility. Mean daily starting FSH dose was 371 ± 110 (225–600). Mean number of mature oocytes cryopreserved at the first completed cycle was 9.7 ± 7.5 (0–43). However, 21% of started cycles were either cancelled before egg retrieval or resulted in 0–3 mature oocytes retrieved. Therefore, women considering oocyte cryopreservation for prevention of age-related fertility decline should be encouraged to perform this procedure at younger age than, preferably before 35.