Arterial stiffness is increased in healthy subjects with a positive family history of hypertension. (17th November 2015)

• Record Type: Journal Article
• Authors: Liu, Jinbo; Wang, Hongyu; Zhao, Hongwei; Liu, Huan; Li, Lihong; Zhou, Yingyan
• Is Part Of: Clinical and experimental hypertension. Volume 37:Number 8(2015)
• Page Start: 622
• Page End: 626
• Publication Date: 2015-11-17
• Subjects: Arterial stiffness -- arteriosclerosis -- family history -- hypertension -- pulse wave velocity; Hypertension -- Chemotherapy -- Periodicals; Hypotensive agents -- Periodicals; 616.132
• DOI: 10.3109/10641963.2015.1036061
• Languages: English
• ISSNs: 1064-1963

Abstract

Abstract: A positive family history of hypertension is a risk factor for cardiovascular diseases. We investigated the value of pulse wave velocity (PWV) in healthy subjects with a positive family history of hypertension. 255 healthy subjects (M/F: 75/180) were divided into two groups according to without (group 1) or with (group 2) a positive family history of hypertension. Carotid-femoral pulse wave velocity (CF-PWV) was measured by Complior apparatus. Our results showed that CF-PWV was significantly higher in group 2 than in group 1 (7.90 ± 1.31 versus 7.32 ± 1.15 m/s, p < 0.001). High-density lipoprotein cholesterol (HDL-C) was significantly higher in group 1 than in group 2. Multiple linear regressions showed that age, family history, GLU, and MAP were independent influencing factors of CF-PWV in the entire study group. Our present study showed PWV is significantly higher in healthy subjects with a positive family history of hypertension. Family history might play an important role in this process.