Comprehensive review on additives of topical dosage forms for drug delivery. (17th November 2015)

• Record Type: Journal Article
• Authors: Garg, Tarun; Rath, Goutam; Goyal, Amit K.
• Is Part Of: Drug delivery. Volume 22:Number 8(2015:Nov.)
• Page Start: 969
• Page End: 987
• Publication Date: 2015-11-17
• Subjects: Additives -- cream -- liniments -- lotions -- topical dosage forms; Drug delivery systems -- Periodicals; Drug targeting -- Periodicals; 615.05
• DOI: 10.3109/10717544.2013.879355
• Languages: English
• ISSNs: 1071-7544

Abstract

Abstract: Skin is the largest organ of the human body and plays the most important role in protecting against pathogen and foreign matter. Three important modes such as topical, regional and transdermal are widely used for delivery of various dosage forms. Among these modes, the topical dosage forms are preferred because it provides local therapeutic activity when applied to the skin or mucous membranes. Additives or pharmaceutical excipients (non-drug component of dosage form) are used as inactive ingredients in dosage form or tools for structuring dosage forms. The main use of topical dosage form additives are controling the extent of absorption, maintaining the viscosity, improving the stability as well as organoleptic property and increasing the bulk of the formulation. The overall goal of this article is to provide the clinician with information related to the topical dosage form additives and their current major applications against various diseases.