A new frontier for an old drug? A word of caution for beta-blockers in sepsis!. (3rd October 2015)

• Record Type: Journal Article
• Authors: Maybauer, Marc O.; Maybauer, Dirk M.
• Is Part Of: Current medical research and opinion. Volume 31:Number 10(2015:Oct.)
• Page Start: 1829
• Page End: 1830
• Publication Date: 2015-10-03
• Subjects: Beta blockers -- Esmolol -- Sepsis -- Septic shock; Clinical medicine -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1185/03007995.2015.1085371
• Languages: English
• ISSNs: 0300-7995

Abstract

Abstract: Recent promising findings indicate a possible benefit of β-blockade in septic patients. Ongoing trials on esmolol in septic shock are investigating its hemodynamic effects, focusing on heart rate control and echocardiographic changes, as well as potential anti-inflammatory effects. However, given the complex physiology of sepsis and pharmacological effects on β-blockade, large multi-center trials are essential before such a therapy may be applied safely.