Inhibition of Vascular Endothelial Growth Factor Receptor 3 Reduces Migration of Gastric Cancer Cells. (14th September 2015)

• Record Type: Journal Article
• Authors: Lim, Jaeyoung; Ryu, Ji Hyeon; Kim, Eun-Jin; Ham, Songhee; Kang, Dawon
• Is Part Of: Cancer investigation. Volume 33:Number 8(2015)
• Page Start: 398
• Page End: 404
• Publication Date: 2015-09-14
• Subjects: Cell movement -- Gastric neoplasms -- Vascular endothelial growth factor C -- Vascular endothelial growth factor receptor-3; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2015.1047509
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract : Angiogenesis induced by proangiogenic molecules such as vascular endothelial growth factor (VEGF) is a key process in the progression and metastasis of gastric cancer. In this study, we investigated the role of VEGF-C/VEGF receptor 3 (VEGFR3) axis in cell proliferation and migration/invasion of human gastric cancer cells (hGCCs). VEGF-C did not enhance cell proliferation but increased cell migration/invasion by approximately ∼50% in hGCCs (AGS and SNU-484). MAZ51, a VEGFR3 inhibitor, reduced the VEGF-C-induced increase in migration/invasion by ∼30% ( p < 0.05). These results suggest that VEGFR3 could be a therapeutic target for reducing the metastasis of gastric cancer cells.