Advanced Cancer Patients' Understanding and Perceptions of Phase I Clinical Trials. (26th November 2015)

• Record Type: Journal Article
• Authors: Pawlowski, Jamie; Malik, Laeeq; Mahalingam, Devalingam
• Is Part Of: Cancer investigation. Volume 33:Number 10(2015)
• Page Start: 490
• Page End: 495
• Publication Date: 2015-11-26
• Subjects: Clinical trials -- Medical ethics -- Chemotherapy; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2015.1069833
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract : This questionnaire-based study assessed the understanding and perceptions of cancer patients who were participating in a Phase I clinical trial at baseline and determined any changes after enrollment. Thirty-six patients participated. Less than one-third of respondents (28.5%) thought the purpose of Phase I trials was dose escalation for safety and efficacy. Patients anticipated varying degree of therapeutic benefit ranging from stable disease (47.1%) to complete shrinkage of the tumor (32.4%). No change in measured themes was observed. Patients participating in Phase I trials need further education to improve their understanding of the true intent of early Phase trials.