Effect of donor age and parent-to-child transplant on living-related donor kidney transplantation: a single center's experience of 236 cases. (3rd July 2015)

• Record Type: Journal Article
• Authors: Qiu, Jiang; Wang, Changxi; Liang, Xianwei; Chen, Guodong; Huang, Gang; Fu, Qian; Chen, Lizhong
• Is Part Of: Renal failure. Volume 37:Number 6(2015)
• Page Start: 1007
• Page End: 1012
• Publication Date: 2015-07-03
• Subjects: Kidney transplant -- living donor -- relatives -- survival; Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.3109/0886022X.2015.1052948
• Languages: English
• ISSNs: 0886-022X

Abstract

Abstract: To study the impact of parent-to-child transplant and older donor age on recipients' post-transplant creatinine levels, a total of 236 patients who received living donor kidney transplantation were evaluated for kidney viability based on creatinine (Cr) level. Of the 236 pairings, 113 (48%) were parent-to-child followed by sibling transplants (66, 30%). Recipient Cr levels were significantly higher at 6 months and 3 years post-transplant in the parent-to-child transplants compared to other donor–recipient relationships. In addition, donor age (average age: 44.1 ± 11.5; range: 19–66) contributed to higher recipient post-transplant Cr levels ( p < 0.01). Pre-transplant donor and recipient Cr levels tended to result in higher post-transplant Cr levels in recipients ( p < 0.05). Multivariate logistic regression analysis revealed that the presence of both parent-to-child transplant and older donor significantly increased the risk of elevated post-transplant Cr levels in recipients with an estimated odds ratios ranging from 3.46 (95% CI: 1.71–6.98) at 6 months to 8.04 (3.14–20.56) at 3 years post-transplant. Donor age significantly affected transplant survival as measured by higher recipient post-transplant Cr levels. In addition, parent-to-child transplant pairings, along with older donor age, significantly increased the risk of elevated post-transplant Cr levels in recipients.