Current strategies for targeted delivery of bio-active drug molecules in the treatment of brain tumor. (26th November 2015)

• Record Type: Journal Article
• Authors: Garg, Tarun; Bhandari, Saurav; Rath, Goutam; Goyal, Amit K.
• Is Part Of: Journal of drug targeting. Volume 23:Number 10(2015)
• Page Start: 865
• Page End: 887
• Publication Date: 2015-11-26
• Subjects: Blood brain barrier -- brain tumor -- drug delivery -- drug targeting -- microdialysis; Drug delivery systems -- Periodicals; Drug Delivery Systems; Vehicles; Drug Administration Routes; Drug Evaluation; 615.7
• DOI: 10.3109/1061186X.2015.1029930
• Languages: English
• ISSNs: 1061-186X

Abstract

Abstract: Brain tumor is one of the most challenging diseases to treat. The major obstacle in the specific drug delivery to brain is blood–brain barrier (BBB). Mostly available anti-cancer drugs are large hydrophobic molecules which have limited permeability via BBB. Therefore, it is clear that the protective barriers confining the passage of the foreign particles into the brain are the main impediment for the brain drug delivery. Hence, the major challenge in drug development and delivery for the neurological diseases is to design non-invasive nanocarrier systems that can assist controlled and targeted drug delivery to the specific regions of the brain. In this review article, our major focus to treat brain tumor by study numerous strategies includes intracerebral implants, BBB disruption, intraventricular infusion, convection-enhanced delivery, intra-arterial drug delivery, intrathecal drug delivery, injection, catheters, pumps, microdialysis, RNA interference, antisense therapy, gene therapy, monoclonal/cationic antibodies conjugate, endogenous transporters, lipophilic analogues, prodrugs, efflux transporters, direct conjugation of antitumor drugs, direct targeting of liposomes, nanoparticles, solid–lipid nanoparticles, polymeric micelles, dendrimers and albumin-based drug carriers.