Efficacy of Deferasirox (Exjade®) in Modulation of Iron Overload in Patients with β-Thalassemia Intermedia. (3rd September 2015)

• Record Type: Journal Article
• Authors: Karimi, Mehran; Arandi, Nargess; Haghpanah, Sezaneh; Ansari, Shahla; Azarkeyvan, Azita; Bordbar, Mohammadreza; Safaei, Sanaz
• Is Part Of: Hemoglobin. Volume 39:Number 5(2015)
• Page Start: 327
• Page End: 329
• Publication Date: 2015-09-03
• Subjects: β-Thalassemia intermedia (β-TI) -- chelation therapy -- deferasirox (Exjade® or DFX) -- serum ferritin; Hemoglobinopathy -- Periodicals; Hemoglobin -- Periodicals; Hematology -- Periodicals; Thalassemia -- Periodicals; Blood -- Diseases -- Periodicals; 612.1111
• DOI: 10.3109/03630269.2015.1057735
• Languages: English
• ISSNs: 0363-0269

Abstract

Abstract: Because of insufficient erythropoiesis, peripheral hemolysis and increased gastrointestinal iron absorption, iron overload is still a matter of debate in β-thalassemia intermedia (β-TI) patients, which can be overcome using iron chelators. However, data on use of iron chelators in β-TI patients is highly restricted. The aim of this study was to evaluate the efficacy of oral administration of deferasirox (Exjade® or DFX) by assessment of serum ferritin levels in β-TI patients. In this quasi-experimental study, 50 β-TI patients with serum ferritin levels >1000 ng/mL were selected and received oral DFX for 12 consecutive months. Iron overload was measured by checking serum ferritin levels every 2 months and the results were compared with the baseline level. The mean serum ferritin was decreased during 1 year of chelation therapy without any toxic effect. Although the difference between baseline ferritin and ferritin levels at the end of second month was not remarkable ( p = 0.88), a significant reduction in serum ferritin was observed after 4 ( p = 0.01), 6 ( p = 0.001), 8 ( p < 0.001), 10 ( p < 0.001) and 12 months ( p < 0.001) of chelation therapy compared to its baseline levels. There was no correlation between baseline ferritin levels and age ( p = 0.574). In addition, no statistically significant difference was observed about change in serum ferritin levels after 6 and also 12 months of therapy between patients who had undergone splenectomy and those who did not ( p = 0.796 and 0.859, respectively). Iron chelation therapy with DFX is safe and effective in reducing serum ferritin levels in β-TI patients who suffer from side effects of iron overload.