Strategies for the safe use of colistin. Issue 10 (3rd October 2015)

• Record Type: Journal Article
• Authors: Ortwine, Jessica K; Sutton, Jesse D; Kaye, Keith S; Pogue, Jason M
• Is Part Of: Expert review of anti-infective therapy. Volume 13:Issue 10(2015)
• Page Start: 1237
• Page End: 1247
• Publication Date: 2015-10-03
• Subjects: carbapenem-resistance -- colistimethate -- colistin -- nephrotoxicity -- pharmacokinetics -- polymyxin; Anti-infective agents -- Research -- Periodicals; 616.90461
• DOI: 10.1586/14787210.2015.1070097
• Languages: English
• ISSNs: 1478-7210

Abstract

Abstract : Colistin has re-emerged as an essential antibiotic for the treatment of carbapenem-resistant Gram-negative infections. Unfortunately, its utility is limited by high rates of nephrotoxicity, even at potentially therapeutic concentrations, and an overall lack of understanding on how to optimally administer the agent. In this review, recent advancements in the understanding of the safety and efficacy of colistin are discussed and strategies and suggestions on how to balance the two are described.