Association of serum arginase I with L-arginine, 3-nitrotyrosine, and exhaled nitric oxide in healthy Japanese workers. (1st February 2014)

• Record Type: Journal Article
• Authors: Ogino, K.; Wang, D. H.; Kubo, M.; Obase, Y.; Setiawan, H.; Yan, F.; Takahashi, H.; Zhang, R.; Tsukiyama, Y.; Yoshida, J.; Zou, Y.
• Is Part Of: Free radical research. Volume 48:Number 2(2014:Feb.)
• Page Start: 137
• Page End: 145
• Publication Date: 2014-02-01
• Subjects: arginase I -- fractional exhaled nitric oxide -- L-arginine -- 3-nitrotyrosine -- population study; Free radicals (Chemistry) -- Periodicals; Antioxidants -- Periodicals; Vitamin C -- Periodicals; Vitamin E -- Periodicals; 541.224
• DOI: 10.3109/10715762.2013.842979
• Languages: English
• ISSNs: 1071-5762

Abstract

Abstract: The associations of serum arginase I with serum L-arginine, serum 3-nitrotyrosine, and fractional exhaled nitric oxide (FENO) were evaluated cross-sectionally in healthy Japanese workers. The serum median (minimum–maximum) levels of arginase I, 3-nitrotyrosine, and FENO in healthy people (n = 130) were 14.6 (0.94–108.1) ng/mL, 81.0 (0.27–298.6) pmol/mg protein, and 14.0 (5.0–110.0) parts per billion, respectively. Significant correlations of arginase I with FENO, L-arginine, 3-nitrotyrosine, and percent predicted forced expiratory volume in 1 s (FEV1 (% predicted)) were observed, and correlations of FENO with immunoglobulin E (IgE), NOx, arginase I, and sex and allergy were also observed. By multiple regression analysis, arginase I showed positive associations with FENO and 3-nitrotyrosine, and a negative association with L-arginine; and FENO showed positive associations with IgE and NO2 − + NO3 − (NOx), and a negative association with L-arginine, as well as an association with sex. Moreover, logistic regression analysis showed linear inverse associations of arginase I and 3-nitrotyrosine with L-arginine, and showed linear positive associations of FENO with IgE and NOx. It was concluded that serum arginase I might regulate serum L-arginine and 3-nitrotyrosine via L-arginine, and that IgE or NOx might regulate FENO in a healthy Japanese population.