Giant prolactinoma presenting as a skull base tumor with erosion of the cervical vertebrae: pronounced responsiveness to dopamine agonist treatment. (2nd January 2015)

• Record Type: Journal Article
• Authors: Bjerg, Mia L.; Rosendal, Frederikke; Nielsen, Edith; Ulhøi, Benedikte Palm; Jørgensen, Jens O. L.
• Is Part Of: British journal of neurosurgery. Volume 29:Number 1(2015:Feb.)
• Page Start: 87
• Page End: 89
• Publication Date: 2015-01-02
• Subjects: brain neoplasm -- cervical spine -- macroadenoma -- skull base tumors; Nervous system -- Surgery -- Periodicals; 617.48
• DOI: 10.3109/02688697.2014.952268
• Languages: English
• ISSNs: 0268-8697

Abstract

Abstract: Giant prolactinomas are rare and usually associated with symptoms attributable to hypopituitarism and compression of juxtasellar structures such as the cranial nerves of the cavernous sinus and the optic chiasm. Occasionally, they masquerade as skull base tumors with atypical symptoms. We describe a patient who presented with a low-energy trauma in the neck region that led to the initial diagnosis of a large skull base tumor eroding the cervical vertebrae. After stabilizing surgery, the patient responded to dopamine agonist therapy with normalization of serum prolactin levels and pronounced reduction in tumor volume.