Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function. (3rd July 2015)

• Record Type: Journal Article
• Authors: Golan, Ron; Scovell, Jason M.; Ramasamy, Ranjith
• Is Part Of: Aging male. Volume 18:Number 3(2015:Sep.)
• Page Start: 201
• Page End: 204
• Publication Date: 2015-07-03
• Subjects: Aging -- testosterone -- hypogonadism -- late-onset hypogonadism; Aging -- Periodicals; Men -- Periodicals; Gerontology -- Periodicals; Men -- Health and hygiene -- Periodicals; Aging -- periodicals; Geriatric -- periodicals; Men -- periodicals; Aged -- periodicals; Aged, 80 and over -- periodicals; 612.67
• DOI: 10.3109/13685538.2015.1052392
• Languages: English
• ISSNs: 1368-5538

Abstract

Abstract: Hypogonadism is a condition in which the endogenous secretion of testosterone is either insufficient or inadequate to maintain serum testosterone levels within normal range, and may manifest as a variety of signs and symptoms. Age-related hypogonadism is due to a combination of primary hypogonadism (testicular failure) and secondary hypogonadism (hypothalamic-pituitary axis failure). This review provides insight into the mechanisms resulting in the multifactorial nature of acquired androgen-deficiency, and outlines the current controversy regarding testosterone-replacement therapy in aging males.