Thyroid disruption properties of three indoor dust chemicals tested in Silurana tropicalis tadpoles. Issue 9 (7th May 2019)

• Record Type: Journal Article
• Authors: Carlsson, Gunnar; Pohl, Johannes; Athanassiadis, Ioannis; Norrgren, Leif; Weiss, Jana
• Is Part Of: Journal of applied toxicology. Volume 39:Issue 9(2019)
• Page Start: 1248
• Page End: 1256
• Publication Date: 2019-05-07
• Subjects: metamorphosis -- propyl paraben -- Silurana tropicalis -- TBBPA -- TDCiPP -- thyroid; Toxicology -- Periodicals; Industrial toxicology -- Periodicals; Environmentally induced diseases -- Periodicals; Toxicology -- Periodicals; 615.9005
• DOI: 10.1002/jat.3810
• Languages: English
• ISSNs: 0260-437X

Abstract

Abstract: Indoor dust contains a multitude of industrial chemicals, and ingestion of dust is considered an important exposure route to organic contaminants. Some of these contaminants have been shown to interfere with the thyroid system, which may result in significant consequences on public health. The amphibian metamorphosis is a thyroid hormone‐dependent process, which can be used as an in vivo model for studies on thyroid hormone‐disrupting potency. Three contaminants of indoor dust were tested on metamorphosing Silurana (Xenopus) tropicalis tadpoles. The tested chemicals were Tris (1, 3‐dichloroisopropyl) phosphate (TDCiPP), tetrabromobisphenol‐A (TBBPA) and propylparaben (PrP). Measurements reflecting general growth, development progress and thyroid epithelial cell height were performed on the exposed tadpoles as well as chemical analyses of the exposure water. It was shown that TDCiPP acts as a thyroid hormone‐disrupting chemical in metamorphosing tadpoles by causing increased epithelial cell height in thyroid glands after exposure to a nominal concentration of 0.010 mg/L and in higher concentrations. TBBPA caused reductions in general growth of tadpoles at the nominal concentration 0.125 mg/L, and PrP caused acute toxicity at the nominal concentration 12.5 mg/L. However, no evident indications of specific thyroid‐disrupting effects caused by TBBPA or PrP were observed. Abstract : Indoor dust contains chemicals, which potentially might interfere with the thyroid system. Tris (1, 3‐dichloroisopropyl) phosphate (TDCiPP), tetrabromobisphenol‐A (TBBPA) and propylparaben (PrP) were tested for thyroid hormone‐disrupting potency on metamorphosing Silurana tropicalis tadpoles. TDCiPP caused increased epithelial cell height in the thyroid glands, indicating thyroid hormone‐disrupting properties. TBBPA and PrP caused toxicity but no specific thyroid‐disrupting effects were observed by these chemicals.