Endotipsitis as an indication for pediatric liver transplantation. Issue 4 (2nd May 2019)

• Record Type: Journal Article
• Authors: Juamperez, Javier; Quintero, Jesús; Muntaner, Antoni; Pérez, Mercedes; Len, Oscar; Charco, Ramón
• Is Part Of: Transplant infectious disease. Volume 21:Issue 4(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-05-02
• Subjects: endotipsitis -- liver transplant -- transjugular intrahepatic portosystemic shunt; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.13097
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: Endotipsitis is a rare but severe complication of transjugular intrahepatic portosystemic shunt (TIPS), a device widely used to treat portal hypertension in adults, but sparsely used in children. We report a case of endotipsitis in a 3‐year‐old child affected of biliary atresia. She underwent a Kasai procedure at 3 months of age but, although the bile flow was restored, she presented upper gastrointestinal bleeding due to portal hypertension 1.5 years later. A TIPS was placed in order to control the hemorrhage. A year after TIPS placement, she started presenting repeated episodes of cholangitis. Blood cultures were positive to Enterobacter cloacae . Even with long antibiotic courses, adjusted to blood cultures, infectious signs were observed after antibiotic withdrawal. Device infection was demonstrated through Positron emission tomography‐Computed tomography scan. The patient was listed for liver transplantation, and intravenous antibiotic treatment was maintained until stent removal during the liver transplant 8 months later. No infectious complications were demonstrated after the surgery. To the best of our knowledge, this is the first case report of endotipsitis described in a pediatric patient.