Development of circulating CD4+ T‐cell memory. Issue 7 (5th June 2019)

• Record Type: Journal Article
• Authors: Soon, Megan SF; Engel, Jessica A; Lee, Hyun J; Haque, Ashraful
• Is Part Of: Immunology and cell biology. Volume 97:Issue 7(2019)
• Page Start: 617
• Page End: 624
• Publication Date: 2019-06-05
• Subjects: adaptive immunity -- CD4 T cells -- immunological memory -- lymphocytes; Immunology -- Periodicals; Cytology -- Periodicals; 616.079
• DOI: 10.1111/imcb.12272
• Languages: English
• ISSNs: 0818-9641

Abstract

Abstract: The ability of circulating CD4 + T cells to retain memories of previous antigenic encounters is a cardinal feature of the adaptive immune system. Over the past two decades, since the first description of central and effector memory T cells, many studies have examined molecular mechanisms controlling CD8 + T‐cell memory, with comparatively less research into CD4 + T‐cell memory. Here, we review a number of seminal studies showing that circulating memory CD4 + T cells develop directly from effector cells; and in so doing, preserve features of their effector precursors. We examine mechanisms controlling the development and phenotypes of memory CD4 + T cells, and provide an updated model that accommodates both the central and effector memory paradigm and the diverse T helper cell classification system. Abstract : Here, we review a number of seminal studies that suggest memory CD4 + T cells develop directly from effector phase T helper (Th) cells, and in so doing, preserve certain features of their effector progenitors. A central task is to generate a model for CD4 + T‐cell memory development that accommodates both the central/effector memory paradigm and the highly diverse Th cell classification system.