A four step synthesis of violaceic acid. Issue 12 (22nd March 2018)
- Record Type:
- Journal Article
- Title:
- A four step synthesis of violaceic acid. Issue 12 (22nd March 2018)
- Main Title:
- A four step synthesis of violaceic acid
- Authors:
- Cameron, Alex
Fisher, Brendan
Rizzacasa, Mark A. - Abstract:
- Abstract: The total synthesis of the biaryl ether natural product violaceic acid (1 ) in four steps is described. The steps included a SN Ar reaction between phenol7 and flouroarene12 to afford the biaryl ether13, selective reduction of a nitro group to an amine in the presence of an aldehyde, a Cu mediated Sandmeyer reaction and final hydrolysis to afford the target compound1 . The amine14 was also converted into the known iodide18 which gave impure1 on Pd mediated hydroxide cross coupling. Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 74:Issue 12(2018)
- Journal:
- Tetrahedron
- Issue:
- Volume 74:Issue 12(2018)
- Issue Display:
- Volume 74, Issue 12 (2018)
- Year:
- 2018
- Volume:
- 74
- Issue:
- 12
- Issue Sort Value:
- 2018-0074-0012-0000
- Page Start:
- 1203
- Page End:
- 1206
- Publication Date:
- 2018-03-22
- Subjects:
- Violaceic acid -- Biraryl ether -- SNAr coupling -- Sandmeyer reaction -- Cross coupling
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2017.10.071 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 11417.xml