Radiolabeled polyoxometalate clusters: Kidney dysfunction evaluation and tumor diagnosis by positron emission tomography imaging. (July 2018)

• Record Type: Journal Article
• Authors: Ni, Dalong; Jiang, Dawei; Im, Hyung-Jun; Valdovinos, Hector F.; Yu, Bo; Goel, Shreya; Barnhart, Todd E.; Huang, Peng; Cai, Weibo
• Is Part Of: Biomaterials. Volume 171(2018)
• Page Start: 144
• Page End: 152
• Publication Date: 2018-07
• Subjects: Positron emission tomography -- Kidney dysfunction -- Tumor diagnosis -- EPR effect -- Nanomedicine; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2018.04.019
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Radiolabeled nanoprobes for positron emission tomography (PET) imaging has received special attention over the past decade, allowing for sensitive, non-invasive, and quantitative detection of different diseases. The rapidly renal clearable nanomaterials normally suffer from a low accumulation in the tumor through the enhanced permeability and retention (EPR) effect due to the rapidly reduced concentration in the blood circulation after renal clearance. It is highly important to design radiolabeled nanomaterials which can meet the balance between the rapid renal clearance and strong EPR effect within a suitable timescale. Herein, renal clearable polyoxometalate (POM) clusters of ultra-small size (∼1 nm in diameter) were readily radiolabeled with the oxophilic 89 Zr to obtain 89 Zr-POM clusters, which may allow for efficient staging of kidney dysfunction in a murine model of unilateral ureteral obstruction (UUO). Furthermore, the as-synthesized clusters can accumulate in the tumor through EPR effect and self-assemble into larger nanostructures in the acidic tumor microenvironment for enhanced tumor accumulation, offering an excellent balance between renal clearance and EPR effect. Graphical abstract: Herein, renal clearable polyoxometalate clusters (POM) were readily radiolabeled with the oxophilic 89 Zr to allow for efficient staging of kidney dysfunction in a murine model. Furthermore, the as-synthesized clusters can accumulate in the tumor through enhanced permeability and retention (EPR) effect and self-assemble into larger nanostructures in the acidic tumor microenvironment for enhanced tumor accumulation, offering an excellent balance between renal clearance and EPR effect.